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Back to Progesterone CreamSafety

Progesterone Cream safety information

What to know before starting Progesterone Cream. A licensed clinician reviews your full health history before any prescription is issued.

Important safety information

  • Progesterone cream is not a proven way to protect the lining of the uterus during estrogen therapy. If you use estrogen and still have a uterus, your clinician decides whether you need a different progestogen.
  • Do not use it if you have unexplained vaginal bleeding, have or had breast cancer, have or had blood clots, a stroke or a heart attack, have liver disease, or are pregnant.
  • Taken with estrogen, progestins have been linked to higher risks of breast cancer, heart attack, stroke and blood clots. Share your full health history in your questionnaire.
  • It can make you drowsy or dizzy. Do not drive or use machines until you know how it affects you.
  • Get medical help right away for chest pain, shortness of breath, a sudden severe headache, vision changes, weakness or numbness, or pain or swelling in one leg.
  • Others can absorb it through your skin. Let the cream dry, wash your hands after applying it, and keep children and pets from touching the area.
  • Use only as directed by your prescribing clinician.

If side effects come up

Message your care team — if side effects are disruptive, your clinician can adjust your plan or stop treatment. For a medical emergency, call 911 or go to the nearest emergency room.

This is a summary of key warnings, not complete prescribing information. Share your full health history during your evaluation. A licensed clinician reviews your full health history before any prescription is issued for Progesterone Cream.

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