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Back to Bremelanotide (PT-141) Nasal SpraySafety

Bremelanotide (PT-141) Nasal Spray safety information

What to know before starting Bremelanotide (PT-141) Nasal Spray. A licensed clinician reviews your full health history before any prescription is issued.

Common side effects

  • Nausea is common, especially at first. Other common side effects include flushing, headache, and vomiting.

Important safety information

  • Do not use with uncontrolled high blood pressure or known cardiovascular disease. Bremelanotide can briefly raise blood pressure and lower heart rate after each dose, usually back to baseline within 12 hours. Discuss any heart conditions, blood pressure, and current medications during intake.
  • It can darken patches of skin on the face, gums, or breasts, and the darkening may not go away after stopping.
  • It slows stomach emptying, which can change how medicines taken by mouth are absorbed. Do not use it with naltrexone taken by mouth, and tell your clinician about every medicine you take.
  • Stop using it and contact your clinician if pregnancy is suspected.
  • These safety facts come from the FDA label of the approved bremelanotide injection. The FDA has not approved any bremelanotide nasal spray. Use only as directed by your prescribing clinician.

If side effects come up

Message your care team — if side effects are disruptive, your clinician can adjust your plan or stop treatment. For a medical emergency, call 911 or go to the nearest emergency room.

This is a summary of key warnings, not complete prescribing information. Share your full health history during your evaluation. A licensed clinician reviews your full health history before any prescription is issued for Bremelanotide (PT-141) Nasal Spray.

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